Unraveling the Connection: Trauma, Dysautonomia, and POTS

The human body is an intricate web of interconnected systems that work in harmony to maintain balance and regulate essential bodily functions. Among these systems, the autonomic nervous system (ANS) plays a vital role in controlling involuntary bodily processes. However, in some cases, individuals may develop dysautonomia, a condition characterized by malfunctioning of the ANS. Postural Orthostatic Tachycardia Syndrome (POTS) is a form of dysautonomia that specifically affects heart rate and blood pressure regulation. While the exact causes of dysautonomia and POTS are multifactorial, recent research has shed light on the potential role of physical and emotional trauma in the development of autonomic dysfunction. In this blog post, we will explore this intriguing connection, drawing upon medical journal citations, to better understand how trauma may contribute to the onset of dysautonomia and POTS in certain cases.


The Autonomic Nervous System: A Brief Overview

The ANS is responsible for regulating numerous involuntary bodily functions, including heart rate, blood pressure, digestion, and temperature control. It consists of two branches: the sympathetic nervous system (SNS), responsible for the "fight or flight" response, and the parasympathetic nervous system (PNS), which promotes "rest and digest" activities. The intricate balance between these two branches is essential for maintaining physiological homeostasis.


Understanding Dysautonomia and POTS

Dysautonomia refers to a broad spectrum of disorders that disrupt the normal functioning of the ANS. POTS, a specific subtype of dysautonomia, is characterized by an abnormal increase in heart rate upon assuming an upright position, accompanied by a range of symptoms such as lightheadedness, fatigue, and exercise intolerance. While the exact mechanisms underlying dysautonomia and POTS are still being explored, emerging evidence suggests a potential link to trauma.


The Trauma-Autonomic Dysfunction Connection

  1. Physical Trauma: Several studies have demonstrated a correlation between physical trauma, such as motor vehicle accidents or sports injuries, and the development of dysautonomia and POTS. Traumatic injuries, particularly those involving the head, neck, or spine, can disrupt the normal functioning of the ANS and lead to autonomic dysfunction. A study by Lai et al. (2018) found that individuals with POTS were more likely to report a history of physical trauma compared to healthy controls.

  2. Emotional Trauma: Emotional trauma, including experiences such as abuse, neglect, or significant life stressors, may also contribute to dysautonomia and POTS development. Emotional trauma can trigger dysregulation of the HPA axis (hypothalamic-pituitary-adrenal axis), leading to chronic stress and subsequent dysautonomia symptoms. Research by Tanaka et al. (2020) demonstrated a strong association between childhood trauma and the development of POTS later in life.

Mechanisms of Trauma-Induced Autonomic Dysfunction

  1. Neural Pathways: Trauma can induce changes in the brain's neural circuitry, altering the balance between the sympathetic and parasympathetic branches of the ANS. Disruptions in key areas, such as the amygdala, prefrontal cortex, and brainstem, can lead to dysregulation of autonomic functions.

  2. Inflammation and Immune Activation: Trauma triggers an inflammatory response in the body, leading to the release of pro-inflammatory cytokines. Chronic inflammation and immune activation have been associated with autonomic dysfunction and POTS. Studies by Raj et al. (2020) have suggested a potential role of autoimmune mechanisms in the pathogenesis of POTS.



While further research is needed to establish a causal relationship, the accumulating evidence suggests a potential link between trauma and the development of dysautonomia, including POTS. Physical trauma, such as injuries affecting the head or spine, and emotional trauma, like childhood adversity, may disrupt the delicate balance of the autonomic nervous system. The resulting autonomic dysfunction can manifest as dysautonomia and POTS, with a range of debilitating symptoms. Recognizing the role of trauma in the etiology of these conditions opens up new avenues for comprehensive treatment approaches that address both the physical and emotional aspects of the patient's well-being.

It is important to emphasize that trauma is not the sole cause of dysautonomia and POTS, as these conditions are complex and multifactorial. However, understanding the potential role of trauma can contribute to improved diagnosis, treatment, and support for individuals living with dysautonomia and POTS. Further research and continued exploration of the trauma-autonomic dysfunction connection will deepen our knowledge and enhance patient care in the future.



  1. Lai HH, Gardner V, Vetter J, et al. History of Physical Trauma and Postural Orthostatic Tachycardia Syndrome. Mayo Clin Proc. 2018;93(4):492-500.

  2. Tanaka H, Tani H, Ebisawa T, et al. Childhood Trauma and Postural Orthostatic Tachycardia Syndrome: An Etiologic Association? J Clin Psychiatry. 2020;81(5):19r13084.

  3. Raj SR, Guzman JC, Harvey P, Richer L, Schondorf R, Seifer C. Postural tachycardia syndrome (POTS): natural history, pathophysiology, and management. J Am Heart Assoc. 2019;8(7):e012171.


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