Understanding the Hidden Connections: How MCAS, Hypermobility, and Your Nervous System Work Together

lifestyle medicine Aug 20, 2025

 Insights from Our Recent Educational Group Visit, Hypermobile Groups, with Dr. Cheng Ruan - Every other Tuesday


At Texas Center For Lifestyle Medicine, we believe that true healing happens when patients understand their bodies and feel supported by a community of peers who share similar experiences. Our educational group visit programs embody this philosophy, creating spaces where knowledge meets connection and where patients become active participants in their health journey.

Our recent Hypermobile group visit exemplified this approach beautifully. Led by Dr. Cheng Ruan, the session explored the intricate relationships between Mast Cell Activation Syndrome (MCAS), hypermobility, and nervous system function. What emerged was not just medical information, but a deeper understanding of how these conditions interconnect in ways that many patients—and even some healthcare providers—may not fully grasp.

The Many Names, One Root Cause

One of the most enlightening moments of the session came when Dr. Ruan addressed a question that resonates with so many of our patients: "Can you have dysautonomia flares without mast cell activation?" His answer was both simple and revolutionary: "No. They're the same thing."

This revelation helps explain why patients often feel confused navigating the healthcare system, receiving different diagnoses from different specialists for what may essentially be the same underlying process. As Dr. Ruan explained, the condition you're diagnosed with often depends on which specialist you see:

  • Cardiologists call it POTS (Postural Orthostatic Tachycardia Syndrome)
  • Neurologists call it dysautonomia
  • Allergists call it Mast Cell Activation Syndrome
  • Gastroenterologists might call it SIBO or gastroparesis
  • Other specialists might diagnose it as peripheral neuropathy

While these conditions may present with different symptoms and affect different body systems, Dr. Ruan emphasized that mast cell activation is often the underlying physiology driving these varied presentations.

Understanding MCAS: More Than Just Allergies

Mast Cell Activation Syndrome represents a fundamental dysfunction in how our immune system responds to triggers. Mast cells, which are crucial components of our immune defense, become overactive and release inflammatory chemicals inappropriately. This can manifest as:

  • Allergic-type reactions and flushing of the skin 
  • Digestive disturbances including bloating and constipation
  • Chronic fatigue and brain fog
  • Cardiovascular symptoms
  • Joint pain and muscle weakness

For individuals with hypermobility, this connection is particularly significant. The same connective tissue differences that create joint flexibility may also affect the stability of mast cells, making them more prone to activation.

The Nervous System: Your Body's Control Center

Dr. Ruan spent considerable time exploring how nervous system function influences both MCAS and hypermobility symptoms. The autonomic nervous system, which controls involuntary functions like heart rate, digestion, and blood pressure, can become dysregulated when mast cells are frequently activated.

This creates a cycle where stress and nervous system activation can trigger mast cell release, which in turn affects nervous system function. Understanding this connection opens doors to therapeutic interventions that address root causes rather than just managing symptoms.

Living Well with Hypermobility: Practical Strategies

The session wasn't just about understanding mechanisms—it was about empowering patients with practical tools. Dr. Ruan discussed evidence-based approaches for managing hypermobility-related challenges:

Lifestyle Modifications: Small changes in daily routines can have significant impacts on symptom management and overall wellbeing.

Targeted Exercise: Specific movements and strengthening exercises that support hypermobile joints while avoiding injury.

Nervous System Regulation: Techniques to help calm an overactive nervous system and reduce mast cell triggering.

Nutritional Support: Understanding how diet and supplements can support mast cell stability and overall health.

The Power of Community and Understanding

What makes our group visits special isn't just the expert medical guidance—it's the community that forms when people with similar experiences come together. Participants often share that hearing others describe symptoms they've experienced creates a powerful sense of validation and reduces the isolation that chronic conditions can create.

When patients understand that their seemingly disparate symptoms—the racing heart, the digestive issues, the joint pain, the fatigue—may all stem from the same underlying process, it's both relieving and empowering. Suddenly, their health journey makes sense, and they can approach treatment more strategically.

Your Invitation to Join Our Community

If you're living with hypermobility, MCAS, dysautonomia, or related conditions, you don't have to navigate this journey alone. Our educational group visits provide more than information—they offer community, support, and practical tools you can implement immediately.

Whether you're newly diagnosed or have been managing these conditions for years, there's always more to learn and new connections to make. Our next group visits will continue to explore these important connections while providing the supportive environment our patients have come to value.

Ready to Take the Next Step?

Understanding your health is the first step toward reclaiming it. At Texas Center For Lifestyle Medicine, we're here to support you with innovative, patient-centered care that addresses root causes and empowers you to take charge of your wellbeing.

Contact us today to learn more about our educational group visit programs and discover how they can support your unique health journey.


At Texas Center For Lifestyle Medicine, we're more than a clinic—we're your partners in health. Together, we can navigate the path to better living, one insight at a time.

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